The WashU NEON Compound Collection
The CDD has created a crowd-sourced small molecule collection, the WashU NEON collection, comprised of compounds synthesized or compiled for a variety of hit-to-lead and lead-to-candidate campaigns by CDD and/or other WashU investigators. This expanding chemical library is available free of charge, as pre-plated sets, to all WashU faculty with screen-ready assays to en
able drug discovery research. Should hits be identified from primary screening, additional compound may be provided, upon request, for follow-up validation assays. It is the intent for NEON to generate chemical starting points for in-house medicinal chemistry and drug target potency optimization, and potentially foster collaborative research connections between Wash U investigators. All compounds have been approved by the respective P.I.s for inclusion in the NEON collection.
Compounds are provided as 2µl at 10mM in 100% DMSO in Greiner 651261 96-well PP V-bottom plates. Each plate contains 80 compounds, with Columns 1 and 12 kept empty.
To request a copy of the NEON library, please fill out the required questionnaire.
Direct completed questionnaires and questions to Maxene Ilagan, Director of the HTS Core: ilaganmg@wustl.edu.
Molecular target composition of the NEON compound library
Molecular weight (MW) and lipophilicity (logP) distribution of the NEON library
Molecules with MW ≤500 Da and logP ≤5 correlate with the properties of FDA-approved orally active drugs.
DOI: 10.1016/s0169-409x(00)00129-0
Topological polar surface area (TPSA) and rotatable bond count (RBC) distribution of the NEON library
Molecules with TPSA ≤140 Ų and RBC ≤10 are predictors of cell membrane permeability and oral bioavailability.
DOI: 10.1021/jm020017n