High Throughput Screening Center


The High Throughput Screening Center (HTSC) is a Core facility within CDD that provides plate-based assay services, screenin resources, expertise, automation along with both siRNA and small-molecule compound libraries suitable for cell-based and biochemical assays. Experienced personnel work in partnership with researchers to develop and/or automate assay procedures for just a few plates through full-scale HTS. We support a broad range of projects ranging from basic research, pathway analysis, target identification, and therapeutic drug discovery.

This resource is available to the entire Washington University community as well as other academic institutions and private industry.



  • Plate-based assay measurements
  • Plate-based high-content cellular microscopy imaging
  • Fully and semi automated high-throughput screening
  • Assay development, miniaturization and automation
  • Optimized plate scheduling and automated tracking
  • Small molecule collection totaling >160,000 compounds, representing bioactive molecules, known drugs and diverse chemistry
  • siRNA collections including human phosphatase, kinase, druggable genome, and whole genome libraries
  • Capabilities in conjunction with screening: cell culture, incubation and screening data analysis
  • Access to stand-alone instrumentation
    • Liquid handling
    • Multi-mode plate readers
    • High-content microscopy