High Throughput Screening Center


We provide plate-based assay services, screening resources, expertise, automation along with both siRNA and small-molecule compound libraries suitable for cell-based and biochemical assays. Experienced personnel work in partnership with researchers to develop and/or automate assay procedures for just a few plates through full-scale HTS.

The High-Throughput Screening Core is the combination of two former screening cores: the CGSC and the HTC, housed within the Department of Biochemistry and Molecular Biophysics. This resource is available to the entire Washington University community as well as other academic institutions and private industry.


  • Scientific Director: Maxene Ilagan – ilaganmg@wustl.edu – 314-362-4445
  • Director: John Cooper


  • Plate-based assay measurements
  • Plate-based high-content cellular microscopy imaging
  • Fully automated high-throughput screening
  • Assay development, miniaturization and automation
  • Optimized plate scheduling and automated tracking
  • Small-molecular libraries ranging from 190 up to 100,000 compounds representing known drugs and diverse chemistry
  • siRNA collections including human phosphatase, kinase, druggable genome, whole genome and custom libraries
  • Capabilities in conjunction with screening: cell culture, incubation and screening data analysis
  • Access to stand-alone instrumentation
    • Liquid handling
    • Multi-mode plate readers
    • High-content microscopy